Tmem60 | transmembrane protein 60

Physiological systems

21 / 24 physiological systems tested

7 Significantly impacted by the knock-out

 Homeostasis/metabolism Reproductive system Immune system Hematopoietic system Behavior/neurological Cardiovascular system Renal/urinary system

14 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:9Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

prolonged RR interval1 supporting datasetTmem60em1(IMPC)CcpczhomozygoteEarly adult2.76x10-5 
hyperactivity4 supporting datasetsTmem60em1(IMPC)CcpczhomozygoteEarly adult5.49x10-6 
decreased effector memory T-helper cell number1 supporting datasetTmem60em1(IMPC)CcpczhomozygoteEarly adult5.9x10-6 
increased circulating total protein level1 supporting datasetTmem60em1(IMPC)CcpczhomozygoteEarly adult3.3x10-5 
prolonged QT interval1 supporting datasetTmem60em1(IMPC)CcpczhomozygoteEarly adult2.27x10-5 
decreased heart rate1 supporting datasetTmem60em1(IMPC)CcpczhomozygoteEarly adult9.76x10-5 
abnormal kidney morphology1 supporting datasetTmem60em1(IMPC)CcpczhomozygoteEarly adultN/A * 
male infertility1 supporting datasetTmem60em1(IMPC)CcpczhomozygoteEarly adultN/A * 
decreased anxiety-related response1 supporting datasetTmem60em1(IMPC)CcpczhomozygoteEarly adult1.32x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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