Dtx4 | deltex 4, E3 ubiquitin ligase
Physiological systems
23 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Endocrine/exocrine gland Growth/size/body region Respiratory system Hematopoietic system Behavior/neurological Cardiovascular system Mortality/aging
14 No significant impact
1 Not tested
Data collections
Gene metrics:9Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal thymus morphology | 1 supporting dataset | Dtx4em1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
| impaired glucose tolerance | 2 supporting datasets | Dtx4em1(IMPC)Ccpcz | heterozygote | Early adult | 1.14x10-7 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Dtx4em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| no spontaneous movement | 1 supporting dataset | Dtx4em1(IMPC)Ccpcz | homozygote | E18.5 | N/A * | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Dtx4em1(IMPC)Ccpcz | heterozygote | Early adult | 1.05x10-6 | ||
| enlarged heart | 1 supporting dataset | Dtx4em1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
| enlarged thymus | 1 supporting dataset | Dtx4em1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
| abnormal heart morphology | 1 supporting dataset | Dtx4em1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
| increased airway resistance | 1 supporting dataset | Dtx4em1(IMPC)Ccpcz | heterozygote | Early adult | 6.97x10-5 |
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External links
No external links available for Dtx4.
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| Dtx4em1(IMPC)Ccpcz | Exon Deletion | | mouse |
| Dtx4tm386083(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |