C8a | complement component 8, alpha polypeptide

GeneMGI:2668347

Physiological systems

17 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Immune system Hematopoietic system Behavior/neurological Skeleton

13 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:3Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased exploration in new environment	1 supporting dataset	C8a^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.95x10^-8
increased bone mineral density	1 supporting dataset	C8a^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	5.78x10^-5
increased lymphocyte cell number	1 supporting dataset	C8a^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.36x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for C8a.

Associated images

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Histopathology

There is no histopathology data found for C8a.

IMPC related publications

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External links

No external links available for C8a.

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*C8a^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*C8a^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*C8a^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*C8a^{tm450(L1L2_gt0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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