Kbtbd8 | kelch repeat and BTB (POZ) domain containing 8

GeneMGI:2661430Synonyms: SSEC-51, SSEC 51, +2 more

Physiological systems

17 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Limbs/digits/tail Hematopoietic system Skeleton

11 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased lean body mass	2 supporting datasets	Kbtbd8^em1(IMPC)Tcp	homozygote	Early adult	5.69x10^-11
decreased body length	1 supporting dataset	Kbtbd8^em1(IMPC)Tcp	homozygote	Early adult	8.75x10^-7
decreased mean corpuscular hemoglobin	1 supporting dataset	Kbtbd8^em1(IMPC)Tcp	homozygote	Early adult	2.2x10^-5
increased circulating alanine transaminase level	1 supporting dataset	Kbtbd8^em1(IMPC)Tcp	homozygote	Early adult	2.21x10^-11
decreased circulating alkaline phosphatase level	1 supporting dataset	Kbtbd8^em1(IMPC)Tcp	homozygote	Early adult	4.27x10^-6
increased total body fat amount	2 supporting datasets	Kbtbd8^em1(IMPC)Tcp	homozygote	Early adult	2.5x10^-9
increased circulating aspartate transaminase level	1 supporting dataset	Kbtbd8^em1(IMPC)Tcp	homozygote	Early adult	8.44x10^-5
decreased bone mineral content	1 supporting dataset	Kbtbd8^em1(IMPC)Tcp	homozygote	Early adult	3.86x10^-9
short tibia	1 supporting dataset	Kbtbd8^em1(IMPC)Tcp	homozygote	Early adult	1.61x10^-9
decreased bone mineral density	1 supporting dataset	Kbtbd8^em1(IMPC)Tcp	homozygote	Early adult	9.95x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Kbtbd8.

Associated images

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Histopathology

There is no histopathology data found for Kbtbd8.

IMPC related publications

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External links

No external links available for Kbtbd8.

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*Kbtbd8^em1(IMPC)Tcp*	Exon Deletion	‌	mouse
*Kbtbd8^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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