Synm | synemin, intermediate filament protein
Physiological systems
21 / 24 physiological systems tested
1 Significantly impacted by the knock-out
Behavior/neurological
20 No significant impact
3 Not tested
Data collections
Gene metrics:1Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues
| abnormal vocalization | 1 supporting dataset | Synmtm1.1(KOMP)Vlcg | homozygote | Early adult | 9.98x10-7 |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images Wholemount images | 100% (4/4) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/3) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | Wholemount images | 100% (4/4) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images Wholemount images | 66.67% (2/3) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | Section images Wholemount images | 100% (4/4) | 7.75% (22/284) |
| cerebellum | heterozygote | Section images Wholemount images | 100% (4/4) | 0.56% (3/532) |
Human diseases caused by Synm mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Synm.
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| Synmtm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Synmtm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Synmtm2a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Synmtm2e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |