Ofcc1 | orofacial cleft 1 candidate 1

GeneMGI:2658851Synonyms: ojoplano, Opo

Physiological systems

17 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Homeostasis/metabolism Limbs/digits/tail Hematopoietic system Behavior/neurological

13 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal hindlimb morphology1 supporting datasetOfcc1em1(IMPC)JhomozygoteLate adult6.04x10-6 
decreased grip strength2 supporting datasetsOfcc1em1(IMPC)JhomozygoteEarly adult1.96x10-5 
decreased thigmotaxis2 supporting datasetsOfcc1em1(IMPC)JhomozygoteEarly adult4.99x10-5 
increased circulating phosphate level1 supporting datasetOfcc1em1(IMPC)JhomozygoteLate adult5.12x10-6 
thrombocytopenia1 supporting datasetOfcc1em1(IMPC)JhomozygoteLate adult6.06x10-5 
abnormal startle reflex1 supporting datasetOfcc1em1(IMPC)JhomozygoteLate adult2.82x10-7 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Ofcc1em1(IMPC)JExon Deletionmouse
Ofcc1tm237959(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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