Lrrc8a | leucine rich repeat containing 8A VRAC subunit A

GeneMGI:2652847Synonyms: Lrrc8, SWELL1, +1 more

Physiological systems

15 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Embryo Growth/size/body region Vision/eye Respiratory system Craniofacial Mortality/aging

8 No significant impact

9 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

2Associated diseases

Expression examined in:73Adult tissues

29Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



edema	1 supporting dataset	Lrrc8a^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
abnormal embryo size	1 supporting dataset	Lrrc8a^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
abnormal lung morphology	1 supporting dataset	Lrrc8a^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*
enlarged lung	1 supporting dataset	Lrrc8a^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*
preweaning lethality, complete penetrance	3 supporting datasets	Lrrc8a^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
anophthalmia	1 supporting dataset	Lrrc8a^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
abnormal craniofacial morphology	1 supporting dataset	Lrrc8a^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
abnormal eye morphology	1 supporting dataset	Lrrc8a^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Lrrc8a.

Associated images

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Histopathology

There is no histopathology data found for Lrrc8a.

IMPC related publications

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External links

No external links available for Lrrc8a.

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*Lrrc8a^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell mouse
*Lrrc8a^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Lrrc8a^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell
*Lrrc8a^{tm2a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Lrrc8a^{tm2e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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