Lrrc8a | leucine rich repeat containing 8A VRAC subunit A

GeneMGI:2652847Synonyms: Lrrc8, SWELL1, +1 more

Physiological systems

15 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Embryo Growth/size/body region Vision/eye Respiratory system Craniofacial Mortality/aging

8 No significant impact

9 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

2Associated diseases

Expression examined in:73Adult tissues

29Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



edema	1 supporting dataset	Lrrc8a^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
abnormal embryo size	1 supporting dataset	Lrrc8a^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
abnormal lung morphology	1 supporting dataset	Lrrc8a^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*
enlarged lung	1 supporting dataset	Lrrc8a^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*
preweaning lethality, complete penetrance	3 supporting datasets	Lrrc8a^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
anophthalmia	1 supporting dataset	Lrrc8a^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
abnormal craniofacial morphology	1 supporting dataset	Lrrc8a^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
abnormal eye morphology	1 supporting dataset	Lrrc8a^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for Lrrc8a.

Associated images

Loading...

Histopathology

There is no histopathology data found for Lrrc8a.

IMPC related publications

Loading...

External links

No external links available for Lrrc8a.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*Lrrc8a^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Lrrc8a^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Lrrc8a^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Lrrc8a^{tm2a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Lrrc8a^{tm2e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

My Genes