Xylt1 | xylosyltransferase 1
GeneMGI:2451073
Physiological systems
19 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Pigmentation Integument Growth/size/body region Limbs/digits/tail Behavior/neurological Mortality/aging Craniofacial
12 No significant impact
5 Not tested
Data collections
Gene metrics:7Significant phenotypes
4Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased thigmotaxis | 2 supporting datasets | Xylt1em1(IMPC)J | heterozygote | Early adult | 8.92x10-5 | ||
| abnormal facial morphology | 1 supporting dataset | Xylt1em1(IMPC)J | homozygote | E18.5 | N/A * | ||
| abnormal vocalization | 1 supporting dataset | Xylt1em1(IMPC)J | heterozygote | Early adult | 2.94x10-10 | ||
| abnormal limb morphology | 1 supporting dataset | Xylt1em1(IMPC)J | homozygote | E18.5 | N/A * | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Xylt1em1(IMPC)J | homozygote | Early adult | N/A * | ||
| abnormal behavior | 1 supporting dataset | Xylt1em1(IMPC)J | heterozygote | Early adult | 8.92x10-5 | ||
| abnormal coat/hair pigmentation | 1 supporting dataset | Xylt1em1(IMPC)J | heterozygote | Early adult | 4.2x10-12 |
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Human diseases caused by Xylt1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Xylt1.
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| Xylt1em1(IMPC)J | Exon Deletion | | mouse |