Chd2 | chromodomain helicase DNA binding protein 2

GeneMGI:2448567Synonyms: 2810013C04Rik, 2810040A01Rik, +1 more

Physiological systems

17 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Limbs/digits/tail Nervous system Hematopoietic system Behavior/neurological Skeleton Cardiovascular system

9 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:15Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



short tibia	1 supporting dataset	Chd2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.93x10^-11
increased circulating aspartate transaminase level	1 supporting dataset	Chd2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	5.27x10^-8
decreased body length	1 supporting dataset	Chd2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.17x10^-6
abnormal sinus arrhythmia	1 supporting dataset	Chd2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.07x10^-8
decreased mean platelet volume	1 supporting dataset	Chd2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	7.47x10^-6
increased grip strength	2 supporting datasets	Chd2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	5.44x10^-12
increased circulating alanine transaminase level	1 supporting dataset	Chd2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.81x10^-5
decreased prepulse inhibition	1 supporting dataset	Chd2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	6.21x10^-5
abnormal bone structure	1 supporting dataset	Chd2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.86x10^-6
decreased erythrocyte cell number	1 supporting dataset	Chd2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.5x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Chd2.

Associated images

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Histopathology

There is no histopathology data found for Chd2.

IMPC related publications

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External links

No external links available for Chd2.

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*Chd2^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Chd2^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Chd2^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Chd2^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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