Gmps | guanine monophosphate synthetase

GeneMGI:2448526Synonyms: Gm9479

Physiological systems

18 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Immune system Adipose tissue Embryo Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Mortality/aging Cardiovascular system

9 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



decreased lean body mass	2 supporting datasets	Gmps^em1(IMPC)Tcp	heterozygote	Early adult	3.92x10^-6
embryonic lethality prior to organogenesis	1 supporting dataset	Gmps^em1(IMPC)Tcp	homozygote	E9.5	N/A ^*
increased leukocyte cell number	1 supporting dataset	Gmps^em1(IMPC)Tcp	heterozygote	Early adult	2.9x10^-5
abnormal retina vasculature morphology	1 supporting dataset	Gmps^em1(IMPC)Tcp	heterozygote	Early adult	8.17x10^-7
increased total body fat amount	2 supporting datasets	Gmps^em1(IMPC)Tcp	heterozygote	Early adult	6.9x10^-6
preweaning lethality, complete penetrance	3 supporting datasets	Gmps^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
abnormal embryo size	1 supporting dataset	Gmps^em1(IMPC)Tcp	heterozygote	E9.5	N/A ^*
abnormal retina blood vessel morphology	1 supporting dataset	Gmps^em1(IMPC)Tcp	heterozygote	Early adult	1.26x10^-6
abnormal locomotor behavior	1 supporting dataset	Gmps^em1(IMPC)Tcp	heterozygote	Early adult	8.3x10^-5
increased lymphocyte cell number	1 supporting dataset	Gmps^em1(IMPC)Tcp	heterozygote	Early adult	5.23x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Gmps.

Associated images

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Histopathology

There is no histopathology data found for Gmps.

IMPC related publications

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External links

No external links available for Gmps.

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*Gmps^em1(IMPC)Tcp*	Exon Deletion	‌	mouse
*Gmps^{tm82502(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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