Pi4ka | phosphatidylinositol 4-kinase alpha
Physiological systems
19 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Immune system Hematopoietic system Behavior/neurological Mortality/aging
15 No significant impact
5 Not tested
Data collections
Gene metrics:7Significant phenotypes
6Associated diseases
Expression examined in:73Adult tissues
29Embryo tissues
| increased erythrocyte cell number | 1 supporting dataset | Pi4katm1b(EUCOMM)Wtsi | heterozygote | Early adult | 5.84x10-5 | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Pi4katm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| increased hematocrit | 1 supporting dataset | Pi4katm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.99x10-5 | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Pi4katm1b(EUCOMM)Wtsi | homozygote | E9.5 | N/A * | ||
| increased monocyte cell number | 1 supporting dataset | Pi4katm1b(EUCOMM)Wtsi | heterozygote | Early adult | 2x10-10 | ||
| limb grasping | 1 supporting dataset | Pi4katm1b(EUCOMM)Wtsi | heterozygote | Early adult | 9.29x10-6 | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Pi4katm1b(EUCOMM)Wtsi | homozygote | E12.5 | N/A * |
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| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 50% (1/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/1) | 7.75% (22/284) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
Human diseases caused by Pi4ka mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Pi4ka.
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| Pi4katm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Pi4katm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Pi4katm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |