Sfmbt2 | Scm-like with four mbt domains 2

GeneMGI:2447794Synonyms: D2Wsu23e, D330030P06Rik

Physiological systems

22 / 24 physiological systems tested

12 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Embryo Growth/size/body region Nervous system Vision/eye Liver/biliary system Behavior/neurological Mortality/aging Cardiovascular system Craniofacial Renal/urinary system

10 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:21Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



edema	1 supporting dataset	Sfmbt2^em1(IMPC)Mbp	heterozygote	E15.5	N/A ^*
increased freezing behavior	1 supporting dataset	Sfmbt2^em1(IMPC)Mbp	heterozygote	Early adult	1.35x10^-5
abnormal neural tube morphology	1 supporting dataset	Sfmbt2^em1(IMPC)Mbp	homozygote	E9.5	N/A ^*
abnormal lymph node morphology	1 supporting dataset	Sfmbt2^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal liver morphology	1 supporting dataset	Sfmbt2^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal heart morphology	1 supporting dataset	Sfmbt2^em1(IMPC)Mbp	heterozygote	E9.5	N/A ^*
preweaning lethality, complete penetrance	3 supporting datasets	Sfmbt2^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal pharyngeal arch morphology	1 supporting dataset	Sfmbt2^em1(IMPC)Mbp	homozygote	E9.5	N/A ^*
embryonic growth retardation	1 supporting dataset	Sfmbt2^em1(IMPC)Mbp	heterozygote	E15.5	N/A ^*
abnormal neural tube morphology	1 supporting dataset	Sfmbt2^em1(IMPC)Mbp	heterozygote	E9.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Sfmbt2.

Associated images

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Histopathology

There is no histopathology data found for Sfmbt2.

IMPC related publications

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External links

No external links available for Sfmbt2.

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*Sfmbt2^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Sfmbt2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Sfmbt2^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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