Slc24a4 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
Physiological systems
18 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Endocrine/exocrine gland Nervous system Hematopoietic system Mortality/aging
12 No significant impact
6 Not tested
Gene metrics:8Significant phenotypes
4Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
| enlarged thymus | 1 supporting dataset | Slc24a4tm1b(KOMP)Wtsi | heterozygote | Early adult | N/A * | ||
| decreased prepulse inhibition | 2 supporting datasets | Slc24a4tm1b(KOMP)Wtsi | homozygote | Early adult | 3.81x10-5 | ||
| increased circulating cholesterol level | 1 supporting dataset | Slc24a4tm1b(KOMP)Wtsi | heterozygote | Early adult | 5.62x10-6 | ||
| increased circulating fructosamine level | 1 supporting dataset | Slc24a4tm1b(KOMP)Wtsi | heterozygote | Early adult | 7.89x10-5 | ||
| decreased red blood cell distribution width | 1 supporting dataset | Slc24a4tm1b(KOMP)Wtsi | heterozygote | Early adult | 6.02x10-6 | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Slc24a4tm1b(KOMP)Wtsi | homozygote | Early adult | 2.11x10-8 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Slc24a4tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| increased circulating HDL cholesterol level | 1 supporting dataset | Slc24a4tm1b(KOMP)Wtsi | heterozygote | Early adult | 7.77x10-6 |
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| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Slc24a4 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Slc24a4.
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| Slc24a4tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Slc24a4tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |