St18 | suppression of tumorigenicity 18
Physiological systems
19 / 24 physiological systems tested
2 Significantly impacted by the knock-out
Growth/size/body region Hematopoietic system
17 No significant impact
5 Not tested
Data collections
Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| decreased body weight | 4 supporting datasets | St18tm1a(KOMP)Wtsi | homozygote | Early adult | 9x10-7 | ||
| decreased mean corpuscular volume | 1 supporting dataset | St18tm1a(KOMP)Wtsi | homozygote | Early adult | 4.44x10-8 | ||
| thrombocytosis | 1 supporting dataset | St18tm1a(KOMP)Wtsi | homozygote | Early adult | 6.34x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | n/a | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/2) | 0% (0/173) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | n/a | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | n/a | 0.41% (2/491) |
Human diseases caused by St18 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for St18.
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| St18tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| St18tm43247(L1L2_gt1) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |