Anks1 | ankyrin repeat and SAM domain containing 1
Physiological systems
21 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Vision/eye Behavior/neurological Skeleton Mortality/aging Cardiovascular system
16 No significant impact
3 Not tested
Data collections
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:50Adult tissues
0Embryo tissues
| preweaning lethality, incomplete penetrance | 3 supporting datasets | Anks1em1(IMPC)Bay | homozygote | Early adult | N/A * | ||
| increased bone mineral density | 1 supporting dataset | Anks1tm1b(KOMP)Wtsi | homozygote | Early adult | 8.43x10-5 | ||
| increased bone mineral content | 2 supporting datasets | Anks1tm1b(KOMP)Wtsi | homozygote | Early adult | 1.43x10-10 | ||
| abnormal retina blood vessel morphology | 1 supporting dataset | Anks1tm1b(KOMP)Wtsi | homozygote | Early adult | 6.17x10-5 | ||
| thin ventricular wall | 1 supporting dataset | Anks1tm1b(KOMP)Wtsi | homozygote | Early adult | 7.44x10-5 | ||
| decreased thigmotaxis | 2 supporting datasets | Anks1tm1b(KOMP)Wtsi | homozygote | Early adult | 1.53x10-5 | ||
| limb grasping | 1 supporting dataset | Anks1em1(IMPC)Bay | heterozygote | Early adult | 2.15x10-10 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Wholemount images | n/a | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Anks1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Anks1.
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| Anks1em1(IMPC)Bay | Exon Deletion | | mouse |
| Anks1tm1a(KOMP)Mbp | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Anks1tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Anks1tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Anks1tm1e(KOMP)Mbp | Targeted, non-conditional allele | | ES Cell |
| Anks1tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |