Spryd3 | SPRY domain containing 3
GeneMGI:2446175
Physiological systems
22 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Vision/eye Behavior/neurological Cardiovascular system
18 No significant impact
2 Not tested
Data collections
Gene metrics:14Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased circulating alkaline phosphatase level | 1 supporting dataset | Spryd3tm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.33x10-7 | ||
| abnormal retina blood vessel morphology | 1 supporting dataset | Spryd3tm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.21x10-8 | ||
| increased circulating cholesterol level | 1 supporting dataset | Spryd3tm1b(EUCOMM)Hmgu | homozygote | Early adult | 6.88x10-5 | ||
| abnormal lens morphology | 1 supporting dataset | Spryd3tm1b(EUCOMM)Hmgu | homozygote | Early adult | 3.15x10-6 | ||
| abnormal retina vasculature morphology | 1 supporting dataset | Spryd3tm1b(EUCOMM)Hmgu | homozygote | Early adult | 9.57x10-10 | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Spryd3tm1a(EUCOMM)Hmgu | homozygote | Early adult | 7.05x10-6 | ||
| abnormal retina morphology | 1 supporting dataset | Spryd3tm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.18x10-11 | ||
| increased startle reflex | 3 supporting datasets | Spryd3tm1a(EUCOMM)Hmgu | homozygote | Early adult | 1.63x10-6 | ||
| increased circulating aspartate transaminase level | 1 supporting dataset | Spryd3tm1a(EUCOMM)Hmgu | homozygote | Early adult | 5.5x10-6 | ||
| increased startle reflex | 1 supporting dataset | Spryd3tm1b(EUCOMM)Hmgu | homozygote | Early adult | 7.54x10-5 |
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Human diseases caused by Spryd3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Spryd3.
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| Spryd3tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Spryd3tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |