Spryd3 | SPRY domain containing 3

GeneMGI:2446175

Physiological systems

22 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Vision/eye Behavior/neurological Cardiovascular system

18 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:14Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Allele:

Phy. System:



increased circulating alkaline phosphatase level	1 supporting dataset	Spryd3^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.33x10^-7
abnormal retina blood vessel morphology	1 supporting dataset	Spryd3^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.21x10^-8
increased circulating cholesterol level	1 supporting dataset	Spryd3^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	6.88x10^-5
abnormal lens morphology	1 supporting dataset	Spryd3^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.15x10^-6
abnormal retina vasculature morphology	1 supporting dataset	Spryd3^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	9.57x10^-10
increased circulating alkaline phosphatase level	1 supporting dataset	Spryd3^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	7.05x10^-6
abnormal retina morphology	1 supporting dataset	Spryd3^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.18x10^-11
increased startle reflex	3 supporting datasets	Spryd3^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	1.63x10^-6
increased circulating aspartate transaminase level	1 supporting dataset	Spryd3^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	5.5x10^-6
increased startle reflex	1 supporting dataset	Spryd3^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	7.54x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Spryd3.

Associated images

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Histopathology

There is no histopathology data found for Spryd3.

IMPC related publications

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External links

No external links available for Spryd3.

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*Spryd3^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Spryd3^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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