Pde2a | phosphodiesterase 2A, cGMP-stimulated
GeneMGI:2446107
Physiological systems
16 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Growth/size/body region Hematopoietic system Mortality/aging Cardiovascular system
10 No significant impact
8 Not tested
Data collections
Gene metrics:4Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased heart weight | 1 supporting dataset | Pde2aem1(IMPC)H | heterozygote | Early adult | 1.61x10-5 | ||
| increased neutrophil cell number | 1 supporting dataset | Pde2aem1(IMPC)H | heterozygote | Early adult | 5.64x10-6 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Pde2aem1(IMPC)H | homozygote | Early adult | N/A * | ||
| increased circulating bilirubin level | 1 supporting dataset | Pde2aem1(IMPC)H | heterozygote | Early adult | 5.18x10-5 |
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Human diseases caused by Pde2a mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Pde2a.
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| Pde2aem1(IMPC)H | Exon Deletion | | mouse |
| Pde2aem2(IMPC)H | Exon Deletion | | mouse |
| Pde2aem3H | Point Mutation | | mouse |
| Pde2aem4H | Point Mutation | | mouse |
| Pde2atm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Pde2atm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Pde2atm2a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Pde2atm2e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |