Klhl3 | kelch-like 3
Physiological systems
19 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Growth/size/body region Hematopoietic system Cardiovascular system
15 No significant impact
5 Not tested
Data collections
Gene metrics:4Significant phenotypes
2Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
| increased circulating potassium level | 1 supporting dataset | Klhl3tm1b(KOMP)Wtsi | homozygote | Early adult | 4.21x10-20 | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Klhl3tm1b(KOMP)Wtsi | homozygote | Early adult | 4.06x10-6 | ||
| decreased hemoglobin content | 1 supporting dataset | Klhl3tm1b(KOMP)Wtsi | homozygote | Early adult | 6.57x10-8 | ||
| increased heart weight | 1 supporting dataset | Klhl3tm1b(KOMP)Wtsi | homozygote | Early adult | 5.73x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Klhl3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Klhl3.
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| Klhl3tm1a(KOMP)Mbp | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Klhl3tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Klhl3tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Klhl3tm1e(KOMP)Mbp | Targeted, non-conditional allele | | ES Cell |