Rsbn1 | rosbin, round spermatid basic protein 1
Physiological systems
21 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Endocrine/exocrine gland Adipose tissue Growth/size/body region Behavior/neurological Skeleton Mortality/aging
13 No significant impact
3 Not tested
Data collections
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
| abnormal bone structure | 1 supporting dataset | Rsbn1tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 2.32x10-5 | ||
| decreased lean body mass | 1 supporting dataset | Rsbn1tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 8.63x10-5 | ||
| abnormal locomotor behavior | 1 supporting dataset | Rsbn1tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 5.46x10-6 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Rsbn1tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| increased total body fat amount | 1 supporting dataset | Rsbn1tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 3.59x10-5 | ||
| increased circulating cholesterol level | 1 supporting dataset | Rsbn1tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 5.13x10-5 | ||
| abnormal seminal vesicle morphology | 1 supporting dataset | Rsbn1tm1b(EUCOMM)Wtsi | heterozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/4) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/4) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/4) | 0% (0/394) |
| brain | heterozygote | n/a | 0% (0/4) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/4) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/4) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/4) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/4) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/4) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/4) | 1.67% (7/419) |
Human diseases caused by Rsbn1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Rsbn1.
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| Rsbn1tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Rsbn1tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Rsbn1tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Rsbn1tm2e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Rsbn1tm3e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |