Kmt2c | lysine (K)-specific methyltransferase 2C

GeneMGI:2444959Synonyms: HALR, E330008K23Rik, +1 more

Physiological systems

18 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Immune system Growth/size/body region Vision/eye Hematopoietic system Skeleton Mortality/aging

12 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



enlarged spleen	1 supporting dataset	Kmt2c^{em2(IMPC)Marc}	heterozygote	Early adult	N/A ^*
abnormal bone structure	1 supporting dataset	Kmt2c^{em2(IMPC)Marc}	heterozygote	Early adult	2.11x10^-6
increased bone mineral content	1 supporting dataset	Kmt2c^{em2(IMPC)Marc}	heterozygote	Early adult	1.9x10^-6
preweaning lethality, complete penetrance	1 supporting dataset	Kmt2c^{em2(IMPC)Marc}	homozygote	Early adult	N/A ^*
abnormal retina morphology	1 supporting dataset	Kmt2c^{em2(IMPC)Marc}	heterozygote	Early adult	9.94x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Kmt2c.

Associated images

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Histopathology

There is no histopathology data found for Kmt2c.

IMPC related publications

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External links

No external links available for Kmt2c.

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*Kmt2c^{em2(IMPC)Marc}*	Deletion	‌	mouse
*Kmt2c^{tm190385(L1L2_gt1_Del_LacZ)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Kmt2c^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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