Dcaf5 | DDB1 and CUL4 associated factor 5

GeneMGI:2444785Synonyms: BCRP2, 9430020B07Rik, +2 more

Physiological systems

22 / 24 physiological systems tested

11 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Limbs/digits/tail Vision/eye Respiratory system Hematopoietic system Behavior/neurological Skeleton Cardiovascular system Craniofacial

11 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:21Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal spleen morphology	1 supporting dataset	Dcaf5^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased spleen weight	1 supporting dataset	Dcaf5^{em1(IMPC)Ccpcz}	homozygote	Early adult	2.57x10^-11
short tibia	1 supporting dataset	Dcaf5^{em1(IMPC)Ccpcz}	homozygote	Early adult	7.01x10^-10
enlarged heart	1 supporting dataset	Dcaf5^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
decreased body weight	2 supporting datasets	Dcaf5^{em1(IMPC)Ccpcz}	homozygote	Early adult	7.25x10^-6
abnormal heart morphology	1 supporting dataset	Dcaf5^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
enlarged spleen	1 supporting dataset	Dcaf5^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
small spleen	1 supporting dataset	Dcaf5^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal tooth morphology	1 supporting dataset	Dcaf5^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased red blood cell distribution width	1 supporting dataset	Dcaf5^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.41x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dcaf5.

Associated images

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Histopathology

There is no histopathology data found for Dcaf5.

IMPC related publications

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External links

No external links available for Dcaf5.

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*Dcaf5^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Dcaf5^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Dcaf5^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Dcaf5^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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