Sptlc3 | serine palmitoyltransferase, long chain base subunit 3

GeneMGI:2444678Synonyms: C130053K05Rik

Physiological systems

20 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Nervous system Vision/eye

17 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:4Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal optic disk morphology	1 supporting dataset	Sptlc3^{em1(IMPC)Hmgu}	homozygote	Early adult	2.8x10^-5
cataract	1 supporting dataset	Sptlc3^{em1(IMPC)Hmgu}	homozygote	Early adult	2.74x10^-7
increased circulating calcium level	1 supporting dataset	Sptlc3^{em1(IMPC)Hmgu}	homozygote	Early adult	6.68x10^-5
abnormal lens morphology	1 supporting dataset	Sptlc3^{em1(IMPC)Hmgu}	homozygote	Early adult	1.77x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Sptlc3.

Associated images

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Histopathology

There is no histopathology data found for Sptlc3.

IMPC related publications

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External links

No external links available for Sptlc3.

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*Sptlc3^{em1(IMPC)Hmgu}*	Exon Deletion	‌	mouse
*Sptlc3^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell

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