Fnip1 | folliculin interacting protein 1

GeneMGI:2444668Synonyms: A730024A03Rik

Physiological systems

23 / 24 physiological systems tested

13 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Integument Endocrine/exocrine gland Growth/size/body region Muscle Digestive/alimentary Respiratory system Liver/biliary system Hematopoietic system Behavior/neurological Skeleton Cardiovascular system

10 No significant impact

1 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:41Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



abnormal heart morphology	2 supporting datasets	Fnip1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased lung compliance	2 supporting datasets	Fnip1^{em1(IMPC)Ccpcz}	homozygote	Early adult	4.42x10^-10
decreased airway resistance	3 supporting datasets	Fnip1^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.6x10^-8
increased thigmotaxis	4 supporting datasets	Fnip1^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.46x10^-5
decreased grip strength	4 supporting datasets	Fnip1^{em1(IMPC)Ccpcz}	homozygote	Early adult	4.2x10^-9
abnormal spleen morphology	2 supporting datasets	Fnip1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
decreased body weight	1 supporting dataset	Fnip1^{em1(IMPC)Ccpcz}	homozygote	Early adult	2.13x10^-5
decreased lymphocyte cell number	1 supporting dataset	Fnip1^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.12x10^-12
decreased respiratory quotient	1 supporting dataset	Fnip1^{em1(IMPC)Ccpcz}	homozygote	Early adult	6.71x10^-6
abnormal skeletal muscle morphology	1 supporting dataset	Fnip1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Fnip1.

Associated images

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Histopathology

There is no histopathology data found for Fnip1.

IMPC related publications

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External links

No external links available for Fnip1.

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*Fnip1^{em1(IMPC)Ccpcz}*	Inter-exon deletion	‌	mouse
*Fnip1^{tm50343(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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