Dmxl2 | Dmx-like 2

GeneMGI:2444630Synonyms: E130119P06Rik, 6430411K14Rik

Physiological systems

17 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Skeleton Mortality/aging

12 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

6Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, complete penetrance	1 supporting dataset	Dmxl2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased total body fat amount	1 supporting dataset	Dmxl2^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	2.16x10^-5
decreased lean body mass	1 supporting dataset	Dmxl2^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	2.86x10^-5
decreased circulating cholesterol level	1 supporting dataset	Dmxl2^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	4.53x10^-5
decreased bone mineral content	1 supporting dataset	Dmxl2^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	4.38x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dmxl2.

Associated images

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Histopathology

There is no histopathology data found for Dmxl2.

IMPC related publications

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External links

No external links available for Dmxl2.

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*Dmxl2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Dmxl2^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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