Ipo8 | importin 8

GeneMGI:2444611Synonyms: Ranbp8, 6230418K12Rik, +3 more

Physiological systems

18 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Nervous system Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system

13 No significant impact

6 Not tested

Gene metrics:6Significant phenotypes
2Associated diseases
Expression examined in:48Adult tissues
46Embryo tissues

Phenotypes

abnormal optic disk morphology1 supporting datasetIpo8tm1.1(KOMP)VlcghomozygoteEarly adult7.89x10-8 
decreased grip strength1 supporting datasetIpo8tm1.1(KOMP)VlcghomozygoteEarly adult2.56x10-5 
cataract1 supporting datasetIpo8tm1.1(KOMP)VlcghomozygoteEarly adult8.66x10-5 
abnormal retina blood vessel morphology2 supporting datasetsIpo8tm1.1(KOMP)VlcghomozygoteEarly adult4x10-5 
increased mean corpuscular hemoglobin1 supporting datasetIpo8tm1.1(KOMP)VlcgheterozygoteEarly adult1.55x10-5 
decreased exploration in new environment1 supporting datasetIpo8tm1.1(KOMP)VlcghomozygoteEarly adult1.84x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Ipo8tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
mouse
Ipo8tm1.1(KOMP)VlcgReporter-tagged deletion allele (post Cre, with no selection cassette)mouse

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