Ipo8 | importin 8
Physiological systems
18 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Nervous system Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system
13 No significant impact
6 Not tested
Data collections
Gene metrics:6Significant phenotypes
2Associated diseases
Expression examined in:48Adult tissues
46Embryo tissues
| abnormal optic disk morphology | 1 supporting dataset | Ipo8tm1.1(KOMP)Vlcg | homozygote | Early adult | 7.89x10-8 | ||
| decreased grip strength | 1 supporting dataset | Ipo8tm1.1(KOMP)Vlcg | homozygote | Early adult | 2.56x10-5 | ||
| cataract | 1 supporting dataset | Ipo8tm1.1(KOMP)Vlcg | homozygote | Early adult | 8.66x10-5 | ||
| abnormal retina blood vessel morphology | 2 supporting datasets | Ipo8tm1.1(KOMP)Vlcg | homozygote | Early adult | 4x10-5 | ||
| increased mean corpuscular hemoglobin | 1 supporting dataset | Ipo8tm1.1(KOMP)Vlcg | heterozygote | Early adult | 1.55x10-5 | ||
| decreased exploration in new environment | 1 supporting dataset | Ipo8tm1.1(KOMP)Vlcg | homozygote | Early adult | 1.84x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Section images | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
| esophagus | heterozygote | Section images | 100% (2/2) | 1.67% (7/419) |
Human diseases caused by Ipo8 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ipo8.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.