Tars3 | threonyl-tRNA synthetase 3

GeneMGI:2444486Synonyms: Tarsl2, A530046H20Rik

Physiological systems

17 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological Skeleton

10 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



hyperactivity	5 supporting datasets	Tars3^em1(IMPC)J	homozygote	Early adult	5.48x10^-11
increased lean body mass	1 supporting dataset	Tars3^em1(IMPC)J	homozygote	Early adult	3.97x10^-7
increased circulating glucose level	1 supporting dataset	Tars3^em1(IMPC)J	homozygote	Early adult	3.59x10^-5
decreased vertical activity	1 supporting dataset	Tars3^em1(IMPC)J	homozygote	Early adult	5.71x10^-5
decreased circulating total protein level	1 supporting dataset	Tars3^em1(IMPC)J	homozygote	Early adult	5.96x10^-7
increased blood urea nitrogen level	1 supporting dataset	Tars3^em1(IMPC)J	homozygote	Early adult	1.02x10^-5
decreased bone mineral density	1 supporting dataset	Tars3^em1(IMPC)J	homozygote	Early adult	2.73x10^-5
increased leukocyte cell number	1 supporting dataset	Tars3^em1(IMPC)J	homozygote	Early adult	2.09x10^-5
decreased total body fat amount	1 supporting dataset	Tars3^em1(IMPC)J	homozygote	Early adult	1.44x10^-6
decreased startle reflex	1 supporting dataset	Tars3^em1(IMPC)J	homozygote	Early adult	1.25x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tars3.

Associated images

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Histopathology

There is no histopathology data found for Tars3.

IMPC related publications

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External links

No external links available for Tars3.

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*Tars3^em1(IMPC)J*	Exon Deletion	‌	mouse
*Tars3^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Tars3^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Tars3^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Tars3^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Tars3^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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