Phf8 | PHD finger protein 8

GeneMGI:2444341Synonyms: 9830141C09Rik

Physiological systems

18 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Vision/eye Hematopoietic system Cardiovascular system

13 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:



increased circulating cholesterol level	1 supporting dataset	Phf8^{em2(IMPC)Wtsi}	homozygote	Early adult	3.69x10^-6
increased circulating alanine transaminase level	1 supporting dataset	Phf8^tm1dIcs	homozygote	Early adult	1.06x10^-7
decreased lymphocyte cell number	1 supporting dataset	Phf8^tm1dIcs	homozygote	Early adult	3.25x10^-6
increased circulating HDL cholesterol level	1 supporting dataset	Phf8^tm1dIcs	hemizygote	Early adult	7.37x10^-5
abnormal eye anterior chamber depth	2 supporting datasets	Phf8^tm1dIcs	homozygote	Early adult	9.23x10^-6
increased neutrophil cell number	1 supporting dataset	Phf8^tm1dIcs	homozygote	Early adult	1.51x10^-5
increased circulating LDL cholesterol level	1 supporting dataset	Phf8^{em2(IMPC)Wtsi}	homozygote	Early adult	1.46x10^-5
increased circulating HDL cholesterol level	1 supporting dataset	Phf8^{em2(IMPC)Wtsi}	homozygote	Early adult	3.75x10^-5
abnormal eye anterior chamber depth	1 supporting dataset	Phf8^tm1dIcs	hemizygote	Early adult	2.53x10^-5
increased mean corpuscular hemoglobin	1 supporting dataset	Phf8^{em2(IMPC)Wtsi}	hemizygote	Early adult	1.62x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Phf8.

Associated images

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Histopathology

There is no histopathology data found for Phf8.

IMPC related publications

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External links

No external links available for Phf8.

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*Phf8^{em1(IMPC)Marc}*	Deletion	‌	mouse
*Phf8^{em1(IMPC)Wtsi}*	Deletion	‌	mouse
*Phf8^{em2(IMPC)Wtsi}*	Exon Deletion	‌	mouse
*Phf8^tm1aIcs*	KO first allele (reporter-tagged insertion with conditional potential)	‌	es cell mouse
*Phf8^tm1dIcs*	Deletion allele (post-Flp and Cre with no reporter)	‌	mouse
*Phf8^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Phf8^{tm39873(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Phf8^{tm39873(L1L2_gt2)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Phf8^{tm39873(L1L2_gt2_Del_LacZ)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Phf8^{tm39873(pL1L2_GT2_DelLacZ_bsd)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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