Phf8 | PHD finger protein 8
Physiological systems
18 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Vision/eye Hematopoietic system Cardiovascular system
13 No significant impact
6 Not tested
Data collections
Gene metrics:11Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased circulating cholesterol level | 1 supporting dataset | Phf8em2(IMPC)Wtsi | homozygote | Early adult | 3.69x10-6 | ||
| increased circulating alanine transaminase level | 1 supporting dataset | Phf8tm1dIcs | homozygote | Early adult | 1.06x10-7 | ||
| decreased lymphocyte cell number | 1 supporting dataset | Phf8tm1dIcs | homozygote | Early adult | 3.25x10-6 | ||
| increased circulating HDL cholesterol level | 1 supporting dataset | Phf8tm1dIcs | hemizygote | Early adult | 7.37x10-5 | ||
| abnormal eye anterior chamber depth | 2 supporting datasets | Phf8tm1dIcs | homozygote | Early adult | 9.23x10-6 | ||
| increased neutrophil cell number | 1 supporting dataset | Phf8tm1dIcs | homozygote | Early adult | 1.51x10-5 | ||
| increased circulating LDL cholesterol level | 1 supporting dataset | Phf8em2(IMPC)Wtsi | homozygote | Early adult | 1.46x10-5 | ||
| increased circulating HDL cholesterol level | 1 supporting dataset | Phf8em2(IMPC)Wtsi | homozygote | Early adult | 3.75x10-5 | ||
| abnormal eye anterior chamber depth | 1 supporting dataset | Phf8tm1dIcs | hemizygote | Early adult | 2.53x10-5 | ||
| increased mean corpuscular hemoglobin | 1 supporting dataset | Phf8em2(IMPC)Wtsi | hemizygote | Early adult | 1.62x10-5 |
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Human diseases caused by Phf8 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Phf8.
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| Phf8em1(IMPC)Marc | Deletion | | mouse |
| Phf8em1(IMPC)Wtsi | Deletion | | mouse |
| Phf8em2(IMPC)Wtsi | Exon Deletion | | mouse |
| Phf8tm1aIcs | KO first allele (reporter-tagged insertion with conditional potential) | | ES Cell mouse |
| Phf8tm1dIcs | Deletion allele (post-Flp and Cre with no reporter) | | mouse |
| Phf8tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Phf8tm39873(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Phf8tm39873(L1L2_gt2) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Phf8tm39873(L1L2_gt2_Del_LacZ) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Phf8tm39873(pL1L2_GT2_DelLacZ_bsd) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |