G2e3 | G2/M-phase specific E3 ubiquitin ligase
Physiological systems
19 / 24 physiological systems tested
13 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Integument Adipose tissue Growth/size/body region Limbs/digits/tail Hematopoietic system Behavior/neurological Skeleton Cardiovascular system Renal/urinary system
6 No significant impact
5 Not tested
Data collections
Gene metrics:18Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| small uterus | 1 supporting dataset | G2e3em1(IMPC)Tcp | homozygote | Early adult | N/A * | ||
| decreased bone mineral content | 2 supporting datasets | G2e3em1(IMPC)Tcp | homozygote | Early adult | 4.22x10-25 | ||
| abnormal mammary gland morphology | 1 supporting dataset | G2e3em1(IMPC)Tcp | homozygote | Early adult | N/A * | ||
| decreased lean body mass | 2 supporting datasets | G2e3em1(IMPC)Tcp | homozygote | Early adult | 1.76x10-24 | ||
| increased circulating aspartate transaminase level | 1 supporting dataset | G2e3em1(IMPC)Tcp | homozygote | Early adult | 1.46x10-6 | ||
| small kidney | 1 supporting dataset | G2e3em1(IMPC)Tcp | homozygote | Early adult | N/A * | ||
| abnormal skin morphology | 1 supporting dataset | G2e3em1(IMPC)Tcp | homozygote | Early adult | N/A * | ||
| increased total body fat amount | 2 supporting datasets | G2e3em1(IMPC)Tcp | homozygote | Early adult | 3.11x10-22 | ||
| decreased body length | 1 supporting dataset | G2e3em1(IMPC)Tcp | homozygote | Early adult | 2.25x10-16 | ||
| abnormal spleen morphology | 1 supporting dataset | G2e3em1(IMPC)Tcp | homozygote | Early adult | N/A * |
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Human diseases caused by G2e3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for G2e3.
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| G2e3em1(IMPC)Tcp | Exon Deletion | | mouse |
| G2e3tm55295(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |