G2e3 | G2/M-phase specific E3 ubiquitin ligase

GeneMGI:2444298Synonyms: 6030408C04Rik, D930034K21Rik

Physiological systems

19 / 24 physiological systems tested

13 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Integument Adipose tissue Growth/size/body region Limbs/digits/tail Hematopoietic system Behavior/neurological Skeleton Cardiovascular system Renal/urinary system

6 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:18Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



small uterus	1 supporting dataset	G2e3^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
decreased bone mineral content	2 supporting datasets	G2e3^em1(IMPC)Tcp	homozygote	Early adult	4.22x10^-25
abnormal mammary gland morphology	1 supporting dataset	G2e3^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
decreased lean body mass	2 supporting datasets	G2e3^em1(IMPC)Tcp	homozygote	Early adult	1.76x10^-24
increased circulating aspartate transaminase level	1 supporting dataset	G2e3^em1(IMPC)Tcp	homozygote	Early adult	1.46x10^-6
small kidney	1 supporting dataset	G2e3^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
abnormal skin morphology	1 supporting dataset	G2e3^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
increased total body fat amount	2 supporting datasets	G2e3^em1(IMPC)Tcp	homozygote	Early adult	3.11x10^-22
decreased body length	1 supporting dataset	G2e3^em1(IMPC)Tcp	homozygote	Early adult	2.25x10^-16
abnormal spleen morphology	1 supporting dataset	G2e3^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for G2e3.

Associated images

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Histopathology

There is no histopathology data found for G2e3.

IMPC related publications

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External links

No external links available for G2e3.

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*G2e3^em1(IMPC)Tcp*	Exon Deletion	‌	mouse
*G2e3^{tm55295(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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