Nr1d1 | nuclear receptor subfamily 1, group D, member 1

GeneMGI:2444210Synonyms: REV-ERBalpha, A530070C09Rik, +1 more

Physiological systems

22 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Skeleton Mortality/aging Cardiovascular system

12 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:21Significant phenotypes

0Associated diseases

Expression examined in:51Adult tissues

62Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:

Life Stage:



decreased total retina thickness	2 supporting datasets	Nr1d1^{tm1(KOMP)Vlcg}	homozygote	Early adult	2.36x10^-22
unresponsive to tactile stimuli	1 supporting dataset	Nr1d1^{tm1.1(KOMP)Vlcg}	homozygote	E18.5	N/A ^*
preweaning lethality, incomplete penetrance	3 supporting datasets	Nr1d1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
abnormal eye morphology	1 supporting dataset	Nr1d1^{tm1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
abnormal eye posterior chamber depth	2 supporting datasets	Nr1d1^{tm1(KOMP)Vlcg}	homozygote	Early adult	3.77x10^-11
abnormal retina inner nuclear layer morphology	2 supporting datasets	Nr1d1^{tm1(KOMP)Vlcg}	homozygote	Early adult	2.56x10^-10
decreased cardiac output	1 supporting dataset	Nr1d1^{tm1(KOMP)Vlcg}	homozygote	Early adult	5.22x10^-10
increased mean corpuscular volume	1 supporting dataset	Nr1d1^Nr1d1	heterozygote	Early adult	4.18x10^-6
decreased thigmotaxis	1 supporting dataset	Nr1d1^{tm1(KOMP)Vlcg}	homozygote	Early adult	1.18x10^-6
increased bone mineral content	2 supporting datasets	Nr1d1^{tm1(KOMP)Vlcg}	homozygote	Early adult	5.87x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Nr1d1.

Associated images

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Histopathology

There is no histopathology data found for Nr1d1.

IMPC related publications

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External links

No external links available for Nr1d1.

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*Nr1d1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Nr1d1^{tm1(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Nr1d1^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Nr1d1^{tm438023(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Nr1d1^{tm438023(L1L2_GT1_LF2A_LacZ_BetactP_neo)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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