Nr1d1 | nuclear receptor subfamily 1, group D, member 1
Physiological systems
22 / 24 physiological systems tested
10 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Skeleton Mortality/aging Cardiovascular system
12 No significant impact
2 Not tested
Gene metrics:21Significant phenotypes
0Associated diseases
Expression examined in:51Adult tissues
62Embryo tissues
| decreased total retina thickness | 2 supporting datasets | Nr1d1tm1(KOMP)Vlcg | homozygote | Early adult | 2.36x10-22 | ||
| unresponsive to tactile stimuli | 1 supporting dataset | Nr1d1tm1.1(KOMP)Vlcg | homozygote | E18.5 | N/A * | ||
| preweaning lethality, incomplete penetrance | 3 supporting datasets | Nr1d1tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| abnormal eye morphology | 1 supporting dataset | Nr1d1tm1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| abnormal eye posterior chamber depth | 2 supporting datasets | Nr1d1tm1(KOMP)Vlcg | homozygote | Early adult | 3.77x10-11 | ||
| abnormal retina inner nuclear layer morphology | 2 supporting datasets | Nr1d1tm1(KOMP)Vlcg | homozygote | Early adult | 2.56x10-10 | ||
| decreased cardiac output | 1 supporting dataset | Nr1d1tm1(KOMP)Vlcg | homozygote | Early adult | 5.22x10-10 | ||
| increased mean corpuscular volume | 1 supporting dataset | Nr1d1Nr1d1 | heterozygote | Early adult | 4.18x10-6 | ||
| decreased thigmotaxis | 1 supporting dataset | Nr1d1tm1(KOMP)Vlcg | homozygote | Early adult | 1.18x10-6 | ||
| increased bone mineral content | 2 supporting datasets | Nr1d1tm1(KOMP)Vlcg | homozygote | Early adult | 5.87x10-7 |
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| adrenal gland | heterozygote | Wholemount images | 100% (7/7) | 0.7% (4/570) |
| aorta | heterozygote | Wholemount images | 50% (2/4) | 0.19% (1/533) |
| bone | heterozygote | Wholemount images | 100% (7/7) | 0% (0/394) |
| brain | heterozygote | Wholemount images | 100% (7/7) | 0.86% (5/579) |
| brainstem | heterozygote | Wholemount images | 100% (7/7) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Wholemount images | 28.57% (2/7) | 0% (0/588) |
| cartilage tissue | heterozygote | Wholemount images | 100% (7/7) | 0.22% (1/454) |
| cecum | heterozygote | n/a | 40% (2/5) | 7.75% (22/284) |
| cerebellum | heterozygote | Wholemount images | 100% (7/7) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Wholemount images | 100% (7/7) | 0.41% (2/491) |
Human diseases caused by Nr1d1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Nr1d1.
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| Nr1d1tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Nr1d1tm1(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Nr1d1tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Nr1d1tm438023(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Nr1d1tm438023(L1L2_GT1_LF2A_LacZ_BetactP_neo) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |