Lmod3 | leiomodin 3 (fetal)

GeneMGI:2444169Synonyms: 5430424A14Rik

Physiological systems

23 / 24 physiological systems tested

16 Significantly impacted by the knock-out

Reproductive system Immune system Integument Endocrine/exocrine gland Adipose tissue Growth/size/body region Muscle Hematopoietic system Cardiovascular system Renal/urinary system Homeostasis/metabolism Pigmentation Nervous system Vision/eye Behavior/neurological Skeleton

7 No significant impact

1 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:45Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal spleen morphology	2 supporting datasets	Lmod3^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
decreased prepulse inhibition	6 supporting datasets	Lmod3^em1(IMPC)Mbp	homozygote	Early adult	2.95x10^-16
decreased grip strength	4 supporting datasets	Lmod3^em1(IMPC)Mbp	homozygote	Early adult	1.44x10^-59
no spontaneous movement	1 supporting dataset	Lmod3^em1(IMPC)Mbp	heterozygote	E18.5	N/A ^*
enlarged spleen	1 supporting dataset	Lmod3^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
enlarged kidney	1 supporting dataset	Lmod3^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal cholesterol homeostasis	1 supporting dataset	Lmod3^em1(IMPC)Mbp	homozygote	Early adult	4.02x10^-5
enlarged lymph nodes	1 supporting dataset	Lmod3^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal adrenal gland morphology	2 supporting datasets	Lmod3^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
decreased body length	1 supporting dataset	Lmod3^em1(IMPC)Mbp	homozygote	Early adult	3.92x10^-8

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Lmod3.

Associated images

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Histopathology

There is no histopathology data found for Lmod3.

IMPC related publications

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External links

No external links available for Lmod3.

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*Lmod3^em1(IMPC)Mbp*	Whole-gene deletion	‌	mouse
*Lmod3^{tm114678(L1L2_Pgk_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Lmod3^{tm1a(KOMP)Mbp}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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