Lmod3 | leiomodin 3 (fetal)
Physiological systems
23 / 24 physiological systems tested
16 Significantly impacted by the knock-out
Reproductive system Immune system Integument Endocrine/exocrine gland Adipose tissue Growth/size/body region Muscle Hematopoietic system Cardiovascular system Renal/urinary system Homeostasis/metabolism Pigmentation Nervous system Vision/eye Behavior/neurological Skeleton
7 No significant impact
1 Not tested
Data collections
Gene metrics:45Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal spleen morphology | 2 supporting datasets | Lmod3em1(IMPC)Mbp | heterozygote | Late adult | N/A * | ||
| decreased prepulse inhibition | 6 supporting datasets | Lmod3em1(IMPC)Mbp | homozygote | Early adult | 2.95x10-16 | ||
| decreased grip strength | 4 supporting datasets | Lmod3em1(IMPC)Mbp | homozygote | Early adult | 1.44x10-59 | ||
| no spontaneous movement | 1 supporting dataset | Lmod3em1(IMPC)Mbp | heterozygote | E18.5 | N/A * | ||
| enlarged spleen | 1 supporting dataset | Lmod3em1(IMPC)Mbp | heterozygote | Late adult | N/A * | ||
| enlarged kidney | 1 supporting dataset | Lmod3em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| abnormal cholesterol homeostasis | 1 supporting dataset | Lmod3em1(IMPC)Mbp | homozygote | Early adult | 4.02x10-5 | ||
| enlarged lymph nodes | 1 supporting dataset | Lmod3em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal adrenal gland morphology | 2 supporting datasets | Lmod3em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| decreased body length | 1 supporting dataset | Lmod3em1(IMPC)Mbp | homozygote | Early adult | 3.92x10-8 |
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Human diseases caused by Lmod3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Lmod3.
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| Lmod3em1(IMPC)Mbp | Whole-gene deletion | | mouse |
| Lmod3tm114678(L1L2_Pgk_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Lmod3tm1a(KOMP)Mbp | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |