Mars2 | methionine-tRNA synthetase 2 (mitochondrial)
Physiological systems
19 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Adipose tissue Growth/size/body region Mortality/aging Renal/urinary system
14 No significant impact
5 Not tested
Data collections
Gene metrics:6Significant phenotypes
4Associated diseases
Expression examined in:48Adult tissues
25Embryo tissues
| decreased urine magnesium level | 1 supporting dataset | Mars2tm1.1(KOMP)Vlcg | heterozygote | Early adult | 3.78x10-61 | ||
| increased total body fat amount | 2 supporting datasets | Mars2tm1.1(KOMP)Vlcg | heterozygote | Early adult | 1.49x10-7 | ||
| decreased fasting circulating glucose level | 1 supporting dataset | Mars2tm1.1(KOMP)Vlcg | heterozygote | Early adult | 5.71x10-6 | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Mars2tm1.1(KOMP)Vlcg | homozygote | E9.5 | N/A * | ||
| decreased lean body mass | 1 supporting dataset | Mars2tm1.1(KOMP)Vlcg | heterozygote | Early adult | 2.04x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Mars2tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Section images | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
| esophagus | heterozygote | Section images | 100% (2/2) | 1.67% (7/419) |
Human diseases caused by Mars2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Mars2.
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| Mars2tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Mars2tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Mars2tm2e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Mars2tm394234(Ifitm2_intron_L1L2_GT0_LF2A_LacZ_BetactP_neo) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |