Mars2 | methionine-tRNA synthetase 2 (mitochondrial)
Physiological systems
19 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Adipose tissue Growth/size/body region Mortality/aging Renal/urinary system
14 No significant impact
5 Not tested
Data collections
Gene metrics:6Significant phenotypes
4Associated diseases
Expression examined in:48Adult tissues
25Embryo tissues
| decreased urine magnesium level | 1 supporting dataset | Mars2tm1.1(KOMP)Vlcg | heterozygote | Early adult | 3.78x10-61 | ||
| increased total body fat amount | 2 supporting datasets | Mars2tm1.1(KOMP)Vlcg | heterozygote | Early adult | 1.49x10-7 | ||
| decreased fasting circulating glucose level | 1 supporting dataset | Mars2tm1.1(KOMP)Vlcg | heterozygote | Early adult | 5.71x10-6 | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Mars2tm1.1(KOMP)Vlcg | homozygote | E9.5 | N/A * | ||
| decreased lean body mass | 1 supporting dataset | Mars2tm1.1(KOMP)Vlcg | heterozygote | Early adult | 2.04x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Mars2tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * |
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| Mars2tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Mars2tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Mars2tm2e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Mars2tm394234(Ifitm2_intron_L1L2_GT0_LF2A_LacZ_BetactP_neo) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |