Sgms1 | sphingomyelin synthase 1

GeneMGI:2444110Synonyms: SMS1gamma, SMS1, +5 more

Physiological systems

18 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological

12 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased grip strength	4 supporting datasets	Sgms1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	9.11x10^-10
increased circulating creatinine level	1 supporting dataset	Sgms1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.21x10^-21
increased lean body mass	1 supporting dataset	Sgms1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	8.59x10^-5
increased circulating magnesium level	1 supporting dataset	Sgms1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.09x10^-6
thrombocytopenia	1 supporting dataset	Sgms1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	6.56x10^-7
decreased mean corpuscular hemoglobin	1 supporting dataset	Sgms1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	6.12x10^-5
male infertility	1 supporting dataset	Sgms1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased mean platelet volume	1 supporting dataset	Sgms1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	9.61x10^-6
increased circulating alkaline phosphatase level	1 supporting dataset	Sgms1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	9.53x10^-11
decreased total body fat amount	1 supporting dataset	Sgms1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.55x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Sgms1.

Associated images

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Histopathology

There is no histopathology data found for Sgms1.

IMPC related publications

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External links

No external links available for Sgms1.

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*Sgms1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Sgms1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Sgms1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Sgms1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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