Bcorl1 | BCL6 co-repressor-like 1
Physiological systems
17 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Homeostasis/metabolism Growth/size/body region Nervous system Vision/eye Hematopoietic system Behavior/neurological Skeleton Cardiovascular system Craniofacial
8 No significant impact
7 Not tested
Data collections
Gene metrics:21Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| cataract | 1 supporting dataset | Bcorl1em1(IMPC)Tcp | hemizygote | Early adult | 1.26x10-7 | ||
| abnormal snout morphology | 1 supporting dataset | Bcorl1em1(IMPC)Tcp | homozygote | Early adult | 1.2x10-5 | ||
| decreased grip strength | 1 supporting dataset | Bcorl1em1(IMPC)Tcp | homozygote | Early adult | 6.24x10-8 | ||
| increased mean corpuscular hemoglobin | 1 supporting dataset | Bcorl1em1(IMPC)Tcp | homozygote | Early adult | 1.55x10-15 | ||
| decreased circulating HDL cholesterol level | 1 supporting dataset | Bcorl1em1(IMPC)Tcp | hemizygote | Early adult | 3.32x10-6 | ||
| decreased circulating cholesterol level | 1 supporting dataset | Bcorl1em1(IMPC)Tcp | hemizygote | Early adult | 4.01x10-6 | ||
| decreased grip strength | 1 supporting dataset | Bcorl1em1(IMPC)Tcp | hemizygote | Early adult | 1.1x10-5 | ||
| cataract | 1 supporting dataset | Bcorl1em1(IMPC)Tcp | homozygote | Early adult | 4.26x10-6 | ||
| increased mean platelet volume | 1 supporting dataset | Bcorl1em1(IMPC)Tcp | homozygote | Early adult | 3x10-9 | ||
| abnormal lens morphology | 1 supporting dataset | Bcorl1em1(IMPC)Tcp | hemizygote | Early adult | 1.05x10-7 |
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Human diseases caused by Bcorl1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Bcorl1.
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| Bcorl1em1(IMPC)Tcp | Intra-exon deletion | | mouse |
| Bcorl1tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Bcorl1tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Bcorl1tm2a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |