Aldh4a1 | aldehyde dehydrogenase 4 family, member A1
Physiological systems
17 / 24 physiological systems tested
2 Significantly impacted by the knock-out
Behavior/neurological Mortality/aging
15 No significant impact
7 Not tested
Data collections
Gene metrics:2Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| preweaning lethality, incomplete penetrance | 3 supporting datasets | Aldh4a1em1(IMPC)Bay | homozygote | Early adult | N/A * | ||
| abnormal locomotor behavior | 1 supporting dataset | Aldh4a1em1(IMPC)Bay | heterozygote | Early adult | 6.32x10-5 |
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Human diseases caused by Aldh4a1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Aldh4a1.
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| Aldh4a1em1(IMPC)Bay | Exon Deletion | | mouse |
| Aldh4a1tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Aldh4a1tm2a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Aldh4a1tm2e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |