Pcif1 | phosphorylated CTD interacting factor 1
Physiological systems
12 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Adipose tissue Growth/size/body region Nervous system Vision/eye Behavior/neurological Skeleton Mortality/aging
5 No significant impact
12 Not tested
Data collections
Gene metrics:10Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased lean body mass | 2 supporting datasets | Pcif1em1(IMPC)Bay | homozygote | Early adult | 7.32x10-8 | ||
| decreased total body fat amount | 2 supporting datasets | Pcif1em1(IMPC)Bay | homozygote | Early adult | 9.53x10-7 | ||
| hyperactivity | 1 supporting dataset | Pcif1em1(IMPC)Bay | homozygote | Early adult | 7.24x10-5 | ||
| decreased thigmotaxis | 2 supporting datasets | Pcif1em1(IMPC)Bay | homozygote | Early adult | 5.55x10-12 | ||
| abnormal bone structure | 1 supporting dataset | Pcif1em1(IMPC)Bay | homozygote | Early adult | 1.04x10-6 | ||
| abnormal optic disk morphology | 1 supporting dataset | Pcif1em1(IMPC)Bay | homozygote | Early adult | 3.22x10-5 | ||
| decreased body length | 1 supporting dataset | Pcif1em1(IMPC)Bay | homozygote | Early adult | 4.61x10-5 | ||
| abnormal eye anterior chamber depth | 1 supporting dataset | Pcif1em1(IMPC)Bay | homozygote | Early adult | 7.07x10-5 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Pcif1em1(IMPC)Bay | homozygote | Early adult | N/A * | ||
| abnormal retina morphology | 2 supporting datasets | Pcif1em1(IMPC)Bay | homozygote | Early adult | 4.62x10-6 |
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Human diseases caused by Pcif1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Pcif1.
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| Pcif1em1(IMPC)Bay | Exon Deletion | | mouse |
| Pcif1tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Pcif1tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |