Iqcb1 | IQ calmodulin-binding motif containing 1

GeneMGI:2443764Synonyms: 6820449I09Rik, NPHP5

Physiological systems

21 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Adipose tissue Growth/size/body region Vision/eye Mortality/aging Cardiovascular system

16 No significant impact

3 Not tested

Gene metrics:6Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

preweaning lethality, incomplete penetrance3 supporting datasetsIqcb1em1(IMPC)BayhomozygoteEarly adultN/A * 
increased heart left ventricle size1 supporting datasetIqcb1em1(IMPC)BayheterozygoteEarly adult5.92x10-7 
increased lean body mass2 supporting datasetsIqcb1em1(IMPC)BayheterozygoteEarly adult6.92x10-6 
decreased total body fat amount2 supporting datasetsIqcb1em1(IMPC)BayheterozygoteEarly adult2.33x10-6 
increased cornea thickness1 supporting datasetIqcb1em1(IMPC)BayheterozygoteEarly adult1.25x10-9 
thick ventricular wall1 supporting datasetIqcb1em1(IMPC)BayheterozygoteEarly adult9.19x10-7 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Iqcb1em1(IMPC)BayExon Deletionmouse
Iqcb1tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Iqcb1tm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell
Iqcb1tm43457(L1L2_gt2)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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