Dlec1 | deleted in lung and esophageal cancer 1

GeneMGI:2443671Synonyms: D630005C06Rik

Physiological systems

22 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Hearing/vestibular/ear Hematopoietic system

18 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

1Associated diseases

Expression examined in:70Adult tissues

0Embryo tissues

Phenotypes

Allele:

Phy. System:



decreased circulating triglyceride level	1 supporting dataset	Dlec1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	9.07x10^-5
decreased mean corpuscular volume	1 supporting dataset	Dlec1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	8.76x10^-5
male infertility	1 supporting dataset	Dlec1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
abnormal auditory brainstem response	1 supporting dataset	Dlec1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.77x10^-7
increased circulating alanine transaminase level	1 supporting dataset	Dlec1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	5.6x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dlec1.

Associated images

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Histopathology

There is no histopathology data found for Dlec1.

IMPC related publications

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External links

No external links available for Dlec1.

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*Dlec1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Dlec1^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Dlec1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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