Rreb1 | ras responsive element binding protein 1
Physiological systems
15 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Hematopoietic system
10 No significant impact
9 Not tested
Data collections
Gene metrics:9Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased circulating serum albumin level | 1 supporting dataset | Rreb1tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 5.52x10-5 | ||
| increased lean body mass | 2 supporting datasets | Rreb1tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 2.43x10-5 | ||
| increased red blood cell distribution width | 1 supporting dataset | Rreb1tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 6.06x10-7 | ||
| decreased hemoglobin content | 1 supporting dataset | Rreb1tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 7.13x10-7 | ||
| decreased total body fat amount | 1 supporting dataset | Rreb1tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 3.55x10-5 | ||
| decreased erythrocyte cell number | 1 supporting dataset | Rreb1tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 4.99x10-7 | ||
| decreased circulating calcium level | 1 supporting dataset | Rreb1tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 6.72x10-6 | ||
| increased leukocyte cell number | 1 supporting dataset | Rreb1tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 6.56x10-5 | ||
| decreased hematocrit | 1 supporting dataset | Rreb1tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 4.89x10-7 |
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Human diseases caused by Rreb1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Rreb1.
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| Rreb1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Rreb1tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Rreb1tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Rreb1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Rreb1tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |