Trib1 | tribbles pseudokinase 1

GeneMGI:2443397Synonyms: Trb1, A530090O15Rik

Physiological systems

21 / 24 physiological systems tested

6 Significantly impacted by the knock-out

 Integument Embryo Growth/size/body region Behavior/neurological Skeleton Mortality/aging

15 No significant impact

3 Not tested

Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:51Adult tissues
62Embryo tissues

Phenotypes

abnormal coat appearance1 supporting datasetTrib1tm1b(KOMP)WtsiheterozygoteEarly adult7.38x10-5 
unresponsive to tactile stimuli1 supporting datasetTrib1tm1b(KOMP)WtsiheterozygoteE18.5N/A * 
decreased bone mineral density1 supporting datasetTrib1tm1b(KOMP)WtsihomozygoteEarly adult2.49x10-9 
abnormal skin coloration1 supporting datasetTrib1tm1b(KOMP)WtsiheterozygoteEarly adult1.24x10-5 
unresponsive to tactile stimuli1 supporting datasetTrib1tm1b(KOMP)WtsihomozygoteE18.5N/A * 
abnormal coat appearance1 supporting datasetTrib1tm1b(KOMP)WtsihomozygoteEarly adult2.44x10-5 
preweaning lethality, incomplete penetrance3 supporting datasetsTrib1tm1b(KOMP)WtsihomozygoteEarly adultN/A * 
abnormal embryo size1 supporting datasetTrib1tm1b(KOMP)WtsihomozygoteE18.5N/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Trib1tm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Trib1tm1b(KOMP)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Trib1tm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell

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