Fgd5 | FYVE, RhoGEF and PH domain containing 5

GeneMGI:2443369Synonyms: ZFYVE23, C330025N11Rik

Physiological systems

22 / 24 physiological systems tested

15 Significantly impacted by the knock-out

Reproductive system Immune system Endocrine/exocrine gland Integument Growth/size/body region Hematopoietic system Cardiovascular system Renal/urinary system Homeostasis/metabolism Embryo Nervous system Vision/eye Liver/biliary system Behavior/neurological Mortality/aging

7 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:28Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



decreased locomotor activity	1 supporting dataset	Fgd5^em1(IMPC)Mbp	heterozygote	Early adult	2.03x10^-13
enlarged spleen	1 supporting dataset	Fgd5^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal liver morphology	1 supporting dataset	Fgd5^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
increased heart weight	2 supporting datasets	Fgd5^em1(IMPC)Mbp	heterozygote	Early adult	1.16x10^-12
decreased thigmotaxis	2 supporting datasets	Fgd5^em1(IMPC)Mbp	heterozygote	Early adult	1.12x10^-9
abnormal neural tube morphology	1 supporting dataset	Fgd5^em1(IMPC)Mbp	heterozygote	E9.5	N/A ^*
small liver	1 supporting dataset	Fgd5^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
small testis	1 supporting dataset	Fgd5^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal retina blood vessel morphology	1 supporting dataset	Fgd5^em1(IMPC)Mbp	heterozygote	Early adult	7.4x10^-6
prenatal lethality prior to heart atrial septation	1 supporting dataset	Fgd5^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Fgd5.

Associated images

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Histopathology

There is no histopathology data found for Fgd5.

IMPC related publications

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External links

No external links available for Fgd5.

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*Fgd5^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Fgd5^{tm42375(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Fgd5^{tm42375(L1L2_Pgk_PM)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Fgd5^{tm42375(L1L2_gt1)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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