Ndufs1 | NADH:ubiquinone oxidoreductase core subunit S1

GeneMGI:2443241Synonyms: 9930026A05Rik, 5830412M15Rik

Physiological systems

19 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Vision/eye Behavior/neurological Mortality/aging

15 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

2Associated diseases

Expression examined in:70Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



abnormal lens morphology	5 supporting datasets	Ndufs1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	4.3x10^-7
preweaning lethality, complete penetrance	1 supporting dataset	Ndufs1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
cataract	1 supporting dataset	Ndufs1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	6.91x10^-8
increased circulating creatinine level	1 supporting dataset	Ndufs1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	5.32x10^-6
increased circulating calcium level	1 supporting dataset	Ndufs1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	5.6x10^-5
decreased circulating triglyceride level	1 supporting dataset	Ndufs1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.77x10^-6
increased circulating sodium level	1 supporting dataset	Ndufs1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	6.51x10^-7
abnormal vitreous body morphology	1 supporting dataset	Ndufs1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	9.45x10^-6
decreased total retina thickness	1 supporting dataset	Ndufs1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	7.47x10^-5
increased circulating lipase level	1 supporting dataset	Ndufs1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	3.44x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ndufs1.

Associated images

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Histopathology

There is no histopathology data found for Ndufs1.

IMPC related publications

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External links

No external links available for Ndufs1.

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*Ndufs1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Ndufs1^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Ndufs1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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