Plekhm1 | pleckstrin homology domain containing, family M (with RUN domain) member 1

GeneMGI:2443207Synonyms: AP162, B2, +1 more

Physiological systems

18 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Limbs/digits/tail Nervous system Vision/eye Skeleton Renal/urinary system

10 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased prepulse inhibition	4 supporting datasets	Plekhm1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.13x10^-16
decreased total body fat amount	2 supporting datasets	Plekhm1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	6.29x10^-14
short tibia	1 supporting dataset	Plekhm1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	5.34x10^-12
increased circulating aspartate transaminase level	1 supporting dataset	Plekhm1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	5.49x10^-18
increased bone mineral density	1 supporting dataset	Plekhm1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.07x10^-16
abnormal vertebrae morphology	1 supporting dataset	Plekhm1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.58x10^-5
increased circulating alanine transaminase level	1 supporting dataset	Plekhm1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.64x10^-5
polycystic kidney	1 supporting dataset	Plekhm1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
increased bone mineral content	2 supporting datasets	Plekhm1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.08x10^-10
abnormal optic disk morphology	1 supporting dataset	Plekhm1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.45x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Plekhm1.

Associated images

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Histopathology

There is no histopathology data found for Plekhm1.

IMPC related publications

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External links

No external links available for Plekhm1.

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*Plekhm1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Plekhm1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Plekhm1^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Plekhm1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Plekhm1^{tm40171(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

My Genes