Terb1 | telomere repeat binding bouquet formation protein 1
Physiological systems
21 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Hematopoietic system
16 No significant impact
3 Not tested
Data collections
Gene metrics:4Significant phenotypes
2Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues
| increased circulating alanine transaminase level | 1 supporting dataset | Terb1tm1b(KOMP)Mbp | heterozygote | Early adult | 1.46x10-6 | ||
| abnormal ovary morphology | 1 supporting dataset | Terb1tm1b(KOMP)Mbp | heterozygote | Early adult | N/A * | ||
| abnormal thymus morphology | 1 supporting dataset | Terb1tm1b(KOMP)Mbp | heterozygote | Early adult | N/A * | ||
| enlarged thymus | 1 supporting dataset | Terb1tm1b(KOMP)Mbp | heterozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/4) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/4) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 0% (0/4) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
| cerebellum | heterozygote | n/a | 0% (0/4) | 0.56% (3/532) |
Human diseases caused by Terb1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Terb1.
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| Terb1tm1a(KOMP)Mbp | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Terb1tm1b(KOMP)Mbp | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Terb1tm1e(KOMP)Mbp | Targeted, non-conditional allele | | ES Cell |
| Terb1tm2a(KOMP)Mbp | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Terb1tm2e(KOMP)Mbp | Targeted, non-conditional allele | | ES Cell |