Rnf43 | ring finger protein 43

GeneMGI:2442609Synonyms: 4732452J19Rik

Physiological systems

17 / 24 physiological systems tested

10 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Integument Adipose tissue Growth/size/body region Limbs/digits/tail Nervous system Hematopoietic system Behavior/neurological Skeleton

7 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:11Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased total body fat amount1 supporting datasetRnf43em1(IMPC)TcphomozygoteEarly adult1.56x10-6 
abnormal skin morphology1 supporting datasetRnf43em1(IMPC)TcphomozygoteEarly adultN/A * 
decreased prepulse inhibition1 supporting datasetRnf43em1(IMPC)TcphomozygoteEarly adult7.05x10-5 
increased hemoglobin content1 supporting datasetRnf43em1(IMPC)TcphomozygoteEarly adult1.45x10-9 
increased mean corpuscular volume1 supporting datasetRnf43em1(IMPC)TcphomozygoteEarly adult1.61x10-35 
increased circulating potassium level1 supporting datasetRnf43em1(IMPC)TcphomozygoteEarly adult2.47x10-5 
decreased locomotor activity1 supporting datasetRnf43em1(IMPC)TcphomozygoteEarly adult2.86x10-5 
increased mean corpuscular hemoglobin1 supporting datasetRnf43em1(IMPC)TcphomozygoteEarly adult8.84x10-35 
enlarged spleen1 supporting datasetRnf43em1(IMPC)TcphomozygoteEarly adultN/A * 
increased hematocrit1 supporting datasetRnf43em1(IMPC)TcphomozygoteEarly adult5.26x10-14 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Rnf43em1(IMPC)TcpExon Deletionmouse
Rnf43tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell

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