Rhbdf2 | rhomboid 5 homolog 2

GeneMGI:2442473Synonyms: iRhom2, cub, +3 more

Physiological systems

22 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Integument Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological Skeleton Cardiovascular system

13 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:20Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:



abnormal coat appearance	5 supporting datasets	Rhbdf2^{em1(IMPC)Wtsi}	heterozygote	Early adult	2.22x10^-11
abnormal vibrissa morphology	3 supporting datasets	Rhbdf2^{em1(IMPC)Wtsi}	homozygote	Early adult	1.6x10^-7
tremors	1 supporting dataset	Rhbdf2^Rhbdf2	homozygote	Early adult	6.92x10^-6
abnormal response to tactile stimuli	1 supporting dataset	Rhbdf2^Rhbdf2	homozygote	Early adult	6.77x10^-6
increased total body fat amount	1 supporting dataset	Rhbdf2^Rhbdf2	homozygote	Early adult	1.98x10^-5
increased circulating magnesium level	1 supporting dataset	Rhbdf2^{em1(IMPC)Wtsi}	homozygote	Early adult	9.33x10^-5
alopecia	1 supporting dataset	Rhbdf2^Rhbdf2	homozygote	Early adult	1.18x10^-19
decreased circulating alkaline phosphatase level	1 supporting dataset	Rhbdf2^Rhbdf2	homozygote	Early adult	9.42x10^-9
increased heart weight	1 supporting dataset	Rhbdf2^Rhbdf2	homozygote	Early adult	3.25x10^-6
abnormal coat appearance	5 supporting datasets	Rhbdf2^{em1(IMPC)Wtsi}	homozygote	Early adult	2.23x10^-17

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Rhbdf2.

Associated images

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Histopathology

There is no histopathology data found for Rhbdf2.

IMPC related publications

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External links

No external links available for Rhbdf2.

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*Rhbdf2^{em1(IMPC)Wtsi}*	Point Mutation	‌	mouse
*Rhbdf2^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Rhbdf2^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Rhbdf2^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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