Hif1an | hypoxia-inducible factor 1, alpha subunit inhibitor

GeneMGI:2442345Synonyms: FIH, A830014H24Rik, +1 more

Physiological systems

20 / 24 physiological systems tested

13 Significantly impacted by the knock-out

Immune system Pigmentation Integument Growth/size/body region Nervous system Vision/eye Liver/biliary system Hematopoietic system Behavior/neurological Skeleton Mortality/aging Cardiovascular system Renal/urinary system

7 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:16Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal spleen morphology	1 supporting dataset	Hif1an^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal kidney morphology	2 supporting datasets	Hif1an^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal coat/hair pigmentation	1 supporting dataset	Hif1an^em1(IMPC)Mbp	homozygote	Early adult	8.86x10^-12
abnormal skin morphology	2 supporting datasets	Hif1an^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
enlarged kidney	2 supporting datasets	Hif1an^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal liver morphology	1 supporting dataset	Hif1an^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal eye morphology	1 supporting dataset	Hif1an^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
decreased exploration in new environment	1 supporting dataset	Hif1an^em1(IMPC)Mbp	homozygote	Early adult	2.28x10^-5
decreased prepulse inhibition	2 supporting datasets	Hif1an^em1(IMPC)Mbp	homozygote	Early adult	1.84x10^-6
small liver	1 supporting dataset	Hif1an^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Hif1an.

Associated images

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Histopathology

There is no histopathology data found for Hif1an.

IMPC related publications

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External links

No external links available for Hif1an.

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*Hif1an^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Hif1an^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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