Cgas | cyclic GMP-AMP synthase

GeneMGI:2442261Synonyms: Mb21d1, E330016A19Rik

Physiological systems

17 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Nervous system Behavior/neurological Skeleton

13 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal behavior	2 supporting datasets	Cgas^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	8.88x10^-5
increased circulating aspartate transaminase level	1 supporting dataset	Cgas^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	1.71x10^-11
abnormal glucose homeostasis	1 supporting dataset	Cgas^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	4.57x10^-5
abnormal bone mineralization	1 supporting dataset	Cgas^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	5.67x10^-5
decreased grip strength	1 supporting dataset	Cgas^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	2.06x10^-5
abnormal tail movements	1 supporting dataset	Cgas^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	1.24x10^-7
increased lactate dehydrogenase level	1 supporting dataset	Cgas^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	5.53x10^-9
increased startle reflex	1 supporting dataset	Cgas^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	4.09x10^-8
decreased circulating amylase level	1 supporting dataset	Cgas^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	8.25x10^-5
decreased prepulse inhibition	1 supporting dataset	Cgas^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	1.77x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for Cgas.

Associated images

Loading...

Histopathology

There is no histopathology data found for Cgas.

IMPC related publications

Loading...

External links

No external links available for Cgas.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*Cgas^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Cgas^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

My Genes