Plekha1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1

GeneMGI:2442213Synonyms: TAPP1, C920009D07Rik

Physiological systems

20 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Endocrine/exocrine gland Vision/eye Skeleton

15 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:4Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



improved glucose tolerance	1 supporting dataset	Plekha1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	5.53x10^-5
small testis	1 supporting dataset	Plekha1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
increased bone mineral content	1 supporting dataset	Plekha1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.86x10^-5
abnormal eye morphology	1 supporting dataset	Plekha1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Plekha1.

Associated images

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Histopathology

There is no histopathology data found for Plekha1.

IMPC related publications

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External links

No external links available for Plekha1.

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*Plekha1^tm1(KOMP)Mbp*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector es cell
*Plekha1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Plekha1^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Plekha1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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