Fam221a | family with sequence similarity 221, member A

GeneMGI:2442161Synonyms: D330028D13Rik

Physiological systems

21 / 24 physiological systems tested

10 Significantly impacted by the knock-out

 Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Growth/size/body region Vision/eye Respiratory system Hematopoietic system Skeleton Cardiovascular system

11 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:16Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

increased hematocrit1 supporting datasetFam221aem1(IMPC)CcpczhomozygoteEarly adult6.17x10-5 
increased erythrocyte cell number1 supporting datasetFam221aem1(IMPC)CcpczhomozygoteEarly adult7.13x10-5 
abnormal lymph node morphology1 supporting datasetFam221aem1(IMPC)CcpczhomozygoteEarly adultN/A * 
kyphosis1 supporting datasetFam221aem1(IMPC)CcpczhomozygoteEarly adult3.04x10-5 
increased airway resistance3 supporting datasetsFam221aem1(IMPC)CcpczhomozygoteEarly adult4.15x10-7 
small testis1 supporting datasetFam221aem1(IMPC)CcpczhomozygoteEarly adultN/A * 
enlarged heart1 supporting datasetFam221aem1(IMPC)CcpczhomozygoteEarly adultN/A * 
abnormal heart morphology1 supporting datasetFam221aem1(IMPC)CcpczhomozygoteEarly adultN/A * 
increased circulating total protein level1 supporting datasetFam221aem1(IMPC)CcpczhomozygoteEarly adult1.75x10-8 
increased CD8-positive, naive alpha-beta T cell number1 supporting datasetFam221aem1(IMPC)CcpczhomozygoteEarly adult6.38x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Fam221aem1(IMPC)CcpczExon Deletionmouse
Fam221atm45213(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector
Fam221atm45213(L1L2_gt2)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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