Tbl1xr1 | transducin (beta)-like 1X-linked receptor 1

GeneMGI:2441730Synonyms: C21, 8030499H02Rik, +5 more

Physiological systems

23 / 24 physiological systems tested

11 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Integument Endocrine/exocrine gland Growth/size/body region Digestive/alimentary Hearing/vestibular/ear Liver/biliary system Behavior/neurological Mortality/aging Cardiovascular system

12 No significant impact

1 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

4Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



enlarged ovary	1 supporting dataset	Tbl1xr1^{tm1b(EUCOMM)Hmgu}	heterozygote	Late adult	N/A ^*
enlarged cecum	1 supporting dataset	Tbl1xr1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	N/A ^*
decreased circulating HDL cholesterol level	1 supporting dataset	Tbl1xr1^{tm1b(EUCOMM)Hmgu}	heterozygote	Late adult	7.33x10^-5
preweaning lethality, incomplete penetrance	1 supporting dataset	Tbl1xr1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
abnormal liver morphology	1 supporting dataset	Tbl1xr1^{tm1b(EUCOMM)Hmgu}	heterozygote	Late adult	N/A ^*
increased heart weight	1 supporting dataset	Tbl1xr1^{tm1b(EUCOMM)Hmgu}	heterozygote	Late adult	4.23x10^-7
increased circulating phosphate level	1 supporting dataset	Tbl1xr1^{tm1b(EUCOMM)Hmgu}	heterozygote	Late adult	1.05x10^-12
increased blood urea nitrogen level	1 supporting dataset	Tbl1xr1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.03x10^-5
abnormal auditory brainstem response	1 supporting dataset	Tbl1xr1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.05x10^-5
increased heart weight	1 supporting dataset	Tbl1xr1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.81x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tbl1xr1.

Associated images

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Histopathology

There is no histopathology data found for Tbl1xr1.

IMPC related publications

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External links

No external links available for Tbl1xr1.

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*Tbl1xr1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Tbl1xr1^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Tbl1xr1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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