Tbl1xr1 | transducin (beta)-like 1X-linked receptor 1
Physiological systems
23 / 24 physiological systems tested
11 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Integument Endocrine/exocrine gland Growth/size/body region Digestive/alimentary Hearing/vestibular/ear Liver/biliary system Behavior/neurological Mortality/aging Cardiovascular system
12 No significant impact
1 Not tested
Data collections
Gene metrics:12Significant phenotypes
4Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| enlarged ovary | 1 supporting dataset | Tbl1xr1tm1b(EUCOMM)Hmgu | heterozygote | Late adult | N/A * | ||
| enlarged cecum | 1 supporting dataset | Tbl1xr1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | N/A * | ||
| decreased circulating HDL cholesterol level | 1 supporting dataset | Tbl1xr1tm1b(EUCOMM)Hmgu | heterozygote | Late adult | 7.33x10-5 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Tbl1xr1tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| abnormal liver morphology | 1 supporting dataset | Tbl1xr1tm1b(EUCOMM)Hmgu | heterozygote | Late adult | N/A * | ||
| increased heart weight | 1 supporting dataset | Tbl1xr1tm1b(EUCOMM)Hmgu | heterozygote | Late adult | 4.23x10-7 | ||
| increased circulating phosphate level | 1 supporting dataset | Tbl1xr1tm1b(EUCOMM)Hmgu | heterozygote | Late adult | 1.05x10-12 | ||
| increased blood urea nitrogen level | 1 supporting dataset | Tbl1xr1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 1.03x10-5 | ||
| abnormal auditory brainstem response | 1 supporting dataset | Tbl1xr1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.05x10-5 | ||
| increased heart weight | 1 supporting dataset | Tbl1xr1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 1.81x10-6 |
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Human diseases caused by Tbl1xr1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Tbl1xr1.
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| Tbl1xr1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Tbl1xr1tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Tbl1xr1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |